explaining your time warner bill

from the new yorker. gave me a good laugh. needed it!

Made me think of my old ATT bill that was supposed to be cheaper than the MCI service. Only after they added on all the taxes, it was always more. I don’t try to figure it out anymore. MCI, not sure it still exists. That company may not have had as many taxes, but if you did have to dispute a problem, you would have to “hold” for at least an hour. OMG.

Anyway, the $1.35 that “somehow goes to Goldman Sachs” is a good one. as well as the $120.32 that goes to “Residuals owed to composer of ‘Please Hold’ music.”

take spring lying down

I don’t believe it. I missed spring by more than a month! Is that because I live in an eternally spring place? where the regional pastime is lying about in a hammock? I must get a hammock. They are not that expensive.

wrong kind, and wrong kind of lying about

Here’s what I learned about hammocks, according to Tommy Homaka, Don’t buy the knotted rope kind that you think of when you think about hammocks — they are hugely uncomfortable.

lying about the right way

Of course, he sells hammocks — knot the traditional knotted rope kind! I’ve never met him, although, I think he lives here in Lake Worth, but had the pleasure of interviewing him years ago. He knot only told me about the wrong kind of hammock to buy, he also told me that people don’t even know how to correctly lie about in a hammock (it’s across). I have knot bought a hammock yet (no time for lying about and I’m not lying about that). and this has been a huge exercise in the correct way to use lay / lie, and I’m really chicken about that grammar rule.

And talking about chickens, that brings me back to spring, or easter at least, which is today, and I didn’t miss it.

Here’s what I found out when I checked out the grammar  (again).

Yahoo questions

“I was laying in bed or lying in bed?”

grammar help 🙂

Best Answer – Chosen by Asker

“You were lying in bed. Laying refers to an object being laid there by something else. Lying refers to something being laid by their own will.”

martha always finds the good stuff

A Mother’s Prayer for Its Child By Tina Fey

Tina Fey Hard At Work

“First, Lord: No tattoos. May neither Chinese symbol for truth nor Winnie-
the-Pooh holding the FSU logo stain her tender haunches.

May she be Beautiful but not Damaged, for it’s the Damage that draws the
creepy soccer coach’s eye, not the Beauty.

When the Crystal Meth is offered, may she remember the parents who cut
her grapes in half And stick with Beer.

Guide her, protect her when crossing the street, stepping onto boats,
swimming in the ocean, swimming in pools, walking near pools, standing on
the subway platform, crossing 86th Street, stepping off of boats, using
mall restrooms, getting on and off escalators, driving on country roads
while arguing, leaning on large windows, walking in parking lots, riding
Ferris wheels, roller-coasters, log flumes, or anything called “Hell
Drop,” “Tower of Torture,” or “The Death Spiral Rock ‘N Zero G Roll
featuring Aerosmith,” and standing on any kind of balcony ever, anywhere,
at any age.

Lead her away from Acting but not all the way to Finance. Something where
she can make her own hours but still feel intellectually fulfilled and get
outside sometimes And not have to wear high heels. What would that be,
Lord? Architecture? Midwifery? Golf course design? I’m asking You, because
if I knew, I’d be doing it, Youdammit.

May she play the Drums to the fiery rhythm of her Own Heart with the
sinewy strength of her Own Arms, so she need Not Lie With Drummers.

Grant her a Rough Patch from twelve to seventeen.Let her draw horses and
be interested in Barbies for much too long, For childhood is short – a
Tiger Flower blooming Magenta for one day – And adulthood is long and dry-
humping in cars will wait.

O Lord, break the Internet forever, that she may be spared the misspelled
invective of her peers And the online marketing campaign for Rape Hostel
V: Girls Just Wanna Get Stabbed.

And when she one day turns on me and calls me a Bitch in front of
Hollister, Give me the strength, Lord, to yank her directly into a cab in
front of her friends, For I will not have that Shit. I will not have it.

And should she choose to be a Mother one day, be my eyes, Lord, that I
may see her, lying on a blanket on the floor at 4:50 A.M., all-at-once
exhausted, bored, and in love with the little creature whose poop is
leaking up its back. “My mother did this for me once,” she will realize as
she cleans feces off her baby’s neck. “My mother did this for me.” And the
delayed gratitude will wash over her as it does each generation and she
will make a Mental Note to call me. And she will forget. But I’ll know,
because I peeped it with Your God eyes.


-Tina Fey

circadian rhythm

Scripps Research Scientists Identify New Mechanism Regulating Daily Biological Rhythms

(What goes around, comes around, and, in fact, its cycles are regulated…)

In a study published November 12 in the Journal of Biological Chemistry, scientists from the Jupiter campus of The Scripps Research Institute announced that they have identified a mechanism that regulates circadian rhythm, the master clock that controls the body’s natural 24-hour cycle. These new findings may help scientists in their search for treatments for sleep disorders, diabetes, obesity as well as some types of cancer.

“It’s well known that the “nuclear receptors” RORα and REV-ERBα, regulate expression of the gene, BMAL1, which is vital to virtually every aspect of human physiology and a core component of the circadian clock,” said Tom Burris, a professor in the Department of Molecular Therapeutics at Scripps Florida who led the study. But, he added, scientists did not how…

By way of explanation, nuclear receptors are proteins that recognize and regulate genes. They have “ports,” so to speak, that scientists can either block or send a protein to bind with, for a desired effect. As a result, the receptors control an organism’s metabolism by activating gene expression.

Gene expression is the scientific term used to describe the process where the information contained in DNA is transcribed into Messenger DNA (MRNA), and then is translated into the proteins necessary to perform critical cell functions. (DNA copies itself backwards into RNA. That process is called transcription. If a gene is not transcribed, it just sits in the cell inactive).

Now, back to the study. Here’s what the Scripps study found: The variations of the distribution of the proteins RORα and REV-ERBα not only regulate the activation of BMAL1, but also of the protein, NPAS2.

And, the scientists asked, since the expression of RORα and REV-ERBα follows a 24-hour circadian pattern, with opposing phases, and leads to the correct circadian pattern of gene expression of BMAL1 and NPAS2, what is the mechanism that governs that?

“We think it’s something of a competition between these two receptors for binding to promoters (proteins that allow expression) of these genes that triggers either the activation (RORα) or repression (REV-ERBα) of the gene,” Burris said.

Learning more about this process is important, because disorders linked to dysfunctional circadian rhythms can be severe and potentially deadly.

“When you’re dealing with circadian rhythm, the most obvious disease target is sleep – for people who do shift work, critical jobs like police work, fire fighting, and medicine,” he said. “If circadian rhythm is disrupted, you’re prone to metabolic disorders like diabetes and obesity and even breast cancer – because the core clock is closely linked to the cell cycle. If your clock goes awry, you run the risk of your cell cycle going awry as well.”

Nuclear receptors have been implicated in a number of cancers, including prostate, breast, and colon cancers, and other diseases as well, including type 2 diabetes, atherosclerosis, and metabolic syndrome.

In addition, nuclear-receptor proteins can be influenced by specific drugs, and so they can be activated by compounds such as the sex hormones, vitamins A and D, and glucocorticoids, which modulate the body’s response to stress. Actually, Scripps scientists have already identified several new drug-like molecules that can influence both of these receptor proteins.

As more is understood about the relationship between these receptors and their gene targets, researchers can consider the possibility of modulating the body’s core clock.

The first author of the study, “Characterization of the Core Mammalian Clock Component, NPAS2, as a REV-­ERBα/RORα Target Gene,” is Christine Crumbley of The Scripps Research Institute. Others authors include Yongjun Wang and Douglas J. Kojetin, also of Scripps Research. For more information, see http://www.jbc.org/content/285/46/35386.abstract

This work was funded by the National Institutes of Health.

The Scripps Research Institute, a large independent, non-profit biomedical research organization, is internationally recognized for its discoveries in immunology, molecular and cellular biology, chemistry, neurosciences, autoimmune, cardiovascular and infectious diseases, and synthetic vaccine development.

Headquartered in La Jolla, California, the institute also includes Scripps Florida, whose researchers focus on basic biomedical science, drug discovery, and technology development. Scripps Florida is located in Jupiter.